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Cozy Garlic Butter Shrimp Scampi Lasagna Bake

A delicious and comforting twist on classic lasagna featuring plump shrimp in a rich garlic butter sauce, layered with noodles and melted cheese. Perfect for a weeknight treat or special occasion.
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Prep Time 10 minutes
Cook Time 35 minutes
Total Time 45 minutes
Course: Dinner, Main Course
Cuisine: Italian-Inspired, Seafood
Ingredients Equipment Method Notes

Ingredients
  

  • Lasagna noodles One box
  • 1 lb Large shrimp peeled and deveined
  • 8 cloves Garlic minced, total
  • 1 cup Butter total (two sticks)
  • 1/4 cup All-purpose flour
  • 2 cups Milk whole or 2%
  • 1 cup Grated Parmesan cheese
  • 1 cup Shredded mozzarella cheese
  • 1/2 cup Fresh parsley chopped, divided use
  • Salt and Pepper to taste
  • 1 tbsp Lemon Juice optional, for brighter flavor

Equipment

  • Large skillet
  • Large Pot
  • Baking dish
  • Whisk

Method
 

  1. Step 1: Cook lasagna noodles according to package directions in a large pot of salted water, slightly undercooking them. Drain well and lay flat on a towel or parchment paper to prevent sticking.
  2. Step 2: In a large skillet, melt 1/2 cup of butter over medium heat. Add 4 cloves of minced garlic and cook for 1-2 minutes until fragrant. Add peeled and deveined shrimp; cook for 2-3 minutes per side until pink and opaque. Remove shrimp and set aside.
  3. Step 3: In the same skillet, melt the remaining 1/2 cup butter over medium heat. Add the remaining 4 cloves of minced garlic and cook for 1-2 minutes until fragrant. Stir in the flour and cook for 1 minute, whisking constantly.
  4. Step 4: Gradually whisk in the milk until the sauce comes to a gentle simmer and thickens. Remove from heat, stir in Parmesan cheese until melted. Season sauce with salt and pepper to taste. (Optional: Add lemon juice or white wine here).
  5. Step 5: Preheat oven to 375°F (190°C).
  6. Step 6: Spoon a thin layer of sauce onto the bottom of a baking dish. Arrange a layer of cooked lasagna noodles over the sauce.
  7. Step 7: Spread another layer of sauce over the noodles. Distribute about a third of the cooked shrimp over the sauce. Sprinkle with some mozzarella cheese. Repeat layers: noodles, sauce, shrimp, mozzarella, until all ingredients are used, ending with a layer of sauce and the remaining mozzarella on top.
  8. Step 8: Cover the baking dish tightly with aluminum foil. Bake in the preheated oven for 25 minutes.
  9. Step 9: Remove foil and bake for an additional 10 minutes, or until the cheese is golden brown and bubbly.
  10. Step 10: Let the lasagna rest for at least 5-10 minutes before slicing. Garnish with chopped fresh parsley before serving.

Notes

Why You’ll Love This Recipe: Fast-ish (under an hour active), Easy, Giftable, Crowd-Pleasing.
Substitutions & Additions: Use oven-ready lasagna noodles to skip boiling. Add ricotta cheese, provolone, or Monterey Jack. Layer with wilted spinach or sautéed mushrooms. Add red pepper flakes for heat. Use fresh basil instead of parsley. Substitute cooked chicken or scallops for shrimp.
Tips for Success: Don't overcook shrimp; they'll cook more in the oven. Ensure sauce is thick but pourable; adjust with more milk if needed. Lay cooked noodles flat to prevent sticking. Rest the lasagna for 5-10 minutes after baking for clean slices. Cover with foil during initial baking to heat evenly.
Storage: Cool completely, cover tightly, and refrigerate for 3-4 days. Reheat portions in microwave or oven (350°F/175°C). Can be frozen for 2-3 months; thaw in fridge before reheating or bake from frozen (takes longer, 45-60 mins covered).
FAQs: Frozen shrimp work, just thaw and pat dry. Assemble up to a day ahead and refrigerate; let sit at room temp 20-30 mins before baking (may need 5-10 mins extra covered bake time). Prevent lumpy sauce by adding milk gradually while whisking vigorously. Add 1/4 cup dry white wine (Pinot Grigio, Sauvignon Blanc) to sauce after garlic in step 4 for classic scampi flavor.